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[Effect of intrauterine growth retardation on insulin sensitivity and plasma adiponectin level in neonates]

Qun Wang1, Xu-Dong Wang, Xin Liu

  • 1Department of Neonatology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China. freeman315@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|August 17, 2018
PubMed

Insights

Intrauterine growth retardation (IUGR) in neonates is linked to reduced insulin sensitivity and lower adiponectin levels. These findings suggest a potential connection between adiponectin and insulin resistance in newborns with IUGR.

Area of Science:

  • Neonatal Endocrinology
  • Metabolic Disorders
  • Perinatal Medicine

Background:

  • Intrauterine growth retardation (IUGR) is a significant concern in neonatology.
  • Insulin sensitivity plays a crucial role in neonatal metabolic health.
  • Adiponectin, a key adipokine, influences glucose and lipid metabolism.

Purpose of the Study:

  • To investigate the impact of IUGR on neonatal insulin sensitivity.
  • To examine the relationship between insulin sensitivity and plasma adiponectin levels in neonates.

Main Methods:

  • Comparison of term neonates with IUGR (n=82) and appropriate for gestational age (AGA) neonates (n=90).
  • Measurement of anthropometric data, glucose, lipids, insulin, and adiponectin levels on day 7 postpartum.
  • Calculation of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Insulin Sensitivity Index (ISI).

Main Results:

  • No significant differences in glucose or lipid profiles between IUGR and AGA groups.
  • IUGR neonates exhibited higher plasma insulin and lower plasma adiponectin levels (P<0.05).
  • IUGR group showed increased HOMA-IR and decreased ISI (P<0.05), with HOMA-IR negatively correlated with adiponectin and birth weight.

Conclusions:

  • Neonates with IUGR demonstrate impaired insulin sensitivity and elevated insulin levels.
  • Reduced plasma adiponectin levels in IUGR neonates may be associated with their decreased insulin sensitivity.
Abstract

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