Related Experiment Video
Updated: Feb 6, 2026

Visual and Microscopic Evaluation of Streptomyces Developmental Mutants
Published on: September 12, 2018
Pyroxazone, a new neuroprotective compound from Streptomyces sp. RAN54
Yoichi Hayakawa1, Taishin Kuriyama2, Yuta Ibusuki2
1Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. hykw@rs.noda.tus.ac.jp.
Abstract:
A neuroprotective compound designated pyroxazone (1) was isolated from the culture broth of Streptomyces sp. RAN54. The molecular formula of 1 was established as C18H14N2O5 by high-resolution FAB-MS. The structure was determined to be a new 2-amino-3H-phenoxazin-3-one derivative by NMR spectroscopic analysis. Pyroxazone (1) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybrid cells from glutamate-induced toxicity with EC50s of 8.2 µM and 1.7 µM, respectively.
Related Concept Videos
Molecules and Compounds
Organic Compounds
Elements and Compounds
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
Solubility of Ionic Compounds
Classification of Elements and Compounds
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
Coordination Compounds and Nomenclature

