Related Experiment Video
Updated: Feb 6, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
CD14+ Monocytic Cytokines: Impact on Outcome in Severely Injured Patients
Nidhi Bhardwaj1, Surbhi Khurana1, Subodh Kumar2
1Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Introduction:
Trauma is one of the leading causes of mortality worldwide. Trauma patients, who presented to the hospital casualty department within 24 h of injury, further admitted to the Surgical Intensive Care Unit were enrolled in this study.
Materials And Methods:
The aim was to study the peripheral blood monocyte activity to produce tumor necrosis factor (TNF-α), interleukin-1 (IL-1) β, IL-6, and IL-8 in severely injured patients after trauma.
Result:
A total of 28 polytrauma patients were enrolled and observed that the levels of TNF-α, IL-1 β, IL-6, and IL-8 were significantly decreased and levels of IL-8 were increased in the fatal patients compared to the healthy controls.
Conclusion:
After trauma, an immediate hyperactivation of circulating monocytes is rapidly followed by a substantial paralysis of cell function. Decreased activity of monocytes can be used to identify potential fatal immunological disruption. Since immunological disruption occurs before clinical symptoms; our study proposes an immunological prognostication score for trauma victims.
More Related Videos
11:34A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
12:58Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
Related Concept Videos
Predicting Reaction Outcomes
Impact of Groups on Groups
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Impact
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Impact of Groups on Individuals