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Olanzapine in the Treatment of Refractory Nausea and Vomiting in Palliative Care Settings
Nishkarsh Gupta1, Sidharth Puri1, Vinod Kumar1
1Department of Onco-Anaesthesiology and Palliative Medicine, Dr. BRAIRCH, AIIMS, New Delhi, India.
Abstract:
The patients often present to palliative care with intractable nausea and vomiting. This may reduce the effectiveness of oral drugs and significantly affects the quality of life of these patients. Despite multiple drugs available for treatment, it is often difficult to control the symptoms. Olanzapine is an atypical antipsychotic and acts on multiple receptors and may help in treating vomiting in a patient with advanced malignancy. We report a case of gallbladder carcinoma who presented to us with intractable vomiting which was not relieved with a combination of traditional antiemetics but showed marked improvement with olanzapine.
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