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Related Concept Videos

Correlation and Causation01:27

Correlation and Causation

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Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
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Photosystem I01:27

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Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
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Photosystem II01:22

Photosystem II

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The multi-protein complex photosystem II (PS II) harvests photons and transfers their energy through its bound pigments to its reaction center, and ultimately to photosystem I (PSI) through the electron transport chain. The pigments responsible for caputirng the light energy in photosystems include chlorophyll a, chlorophyll b, and carotenoids.
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Base Excision Repair01:54

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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Related Experiment Video

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Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates
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Are We Missing Out on Something?

Astha Koolwal Kapoor1, Sushma Bhatnagar1

  • 1Department of Onco-Anaesthesia and Palliative Medicine, Dr. BRA-IRCH, AIIMS, New Delhi, India.

Indian Journal of Palliative Care
|August 17, 2018
PubMed
Summary
This summary is machine-generated.

Patients with advanced cancer face high suicide risk, often linked to severe cancer pain. Effective pain management in palliative care is crucial to mitigate psychiatric distress and suicide risk.

Keywords:
Continuum of carehopelesspalliative physicianquality of life

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Area of Science:

  • Oncology
  • Palliative Care
  • Psychiatry

Background:

  • Advanced cancer patients have a significantly high risk of suicide.
  • Cancer-related pain affects approximately 60% of advanced cancer patients.
  • Pain exacerbates psychiatric disorders and suicide risk in this population.

Observation:

  • A 50-year-old male with advanced mouth floor carcinoma, post-chemotherapy and radiotherapy, presented with severe throat pain.
  • The patient reported increased pain upon swallowing.
  • He had recently attempted suicide by consuming poison due to agitation from severe throat pain.

Findings:

  • The patient's severe throat pain, worsened by recent radiotherapy, was a primary driver of his distress.
  • Cancer pain is a critical symptom requiring adequate management in advanced cancer care.
  • Untreated or poorly managed cancer pain can lead to severe psychological distress and suicidal ideation.

Implications:

  • There is a critical need for comprehensive pain assessment and management in advanced cancer patients.
  • Palliative care and oncology clinics must prioritize addressing cancer pain to prevent adverse psychiatric outcomes.
  • Integrating mental health support with pain management is essential for reducing suicide risk in cancer patients.