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The Notch Pathway in Breast Cancer Progression
Emmanuel N Kontomanolis1, Sofia Kalagasidou2, Stamatia Pouliliou3
1Department of Obstetrics and Gynecology, Democritus University of Thrace, 681 00 Alexandroupolis, Greece.
Thescientificworldjournal
|August 17, 2018
Summary
The Notch signaling pathway significantly impacts breast cancer progression and angiogenesis. Inhibiting Notch offers promising therapeutic strategies for breast cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- The Notch signaling pathway is crucial for mammalian vascular development.
- Dysregulation of Notch signaling is implicated in various cancers, including breast cancer.
Purpose of the Study:
- To review the role of the Notch signaling pathway in breast cancer progression.
- To explore the therapeutic potential of inhibiting Notch signaling in breast cancer.
Main Methods:
- A comprehensive literature search was conducted in MEDLINE, PubMed, and Scopus.
- Articles published from 1973 to 2017 concerning Notch, breast cancer, and angiogenesis were included.
Main Results:
- Notch signaling regulates breast epithelial cell differentiation and is vital in breast cancer progression.
- Notch pathway dysregulation, including overexpression of receptors/ligands, promotes angiogenesis and tumorigenesis.
- Notch signaling interacts with estrogen pathways and influences breast cancer stem cell formation.
Conclusions:
- The Notch pathway plays a significant and multifaceted role in breast tumor progression.
- Inhibition of Notch signaling presents innovative therapeutic opportunities for breast cancer.
- Further research is necessary to establish safe and definitive conclusions for Notch-targeted therapies.
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