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Effects of remote ischemic post-conditioning on platelet activation of AMI patients

Yun-Xia Qian1, Ke-Sheng Dai2, Li-Li Zhao2

  • 1Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Experimental and Therapeutic Medicine
|August 17, 2018
PubMed

Insights

Remote ischemic post-conditioning reduced platelet activation and major adverse cardiac events in acute myocardial infarction patients undergoing primary percutaneous coronary intervention. This intervention improved patient prognosis by mitigating platelet CD62P activation.

Area of Science:

  • Cardiology
  • Hematology
  • Ischemic Heart Disease

Background:

  • Acute myocardial infarction (AMI) treatment focuses on restoring blood flow but carries side effects.
  • Platelet activation is crucial in AMI's occurrence, progression, and treatment.
  • Primary percutaneous coronary intervention (PCI) is a standard AMI treatment.

Purpose of the Study:

  • To evaluate the impact of remote ischemic post-conditioning on platelet activation in AMI patients receiving primary PCI.
  • To assess the effect of this intervention on clinical prognosis and major adverse cardiac events (MACE).

Main Methods:

  • 71 AMI patients were randomized into a control group and an observation group receiving remote ischemic post-conditioning.
  • Flow cytometry measured platelet markers (CD62P, PAC-1).
  • Light transmittance aggregometry assessed platelet aggregation induced by ADP and AA.
  • MACE incidence was tracked over a 6-month follow-up.

Main Results:

  • The observation group showed significantly lower CD62P levels 24 hours post-PCI compared to the control group (P<0.05).
  • Platelet aggregation rates were not detailed but implied to be affected by the intervention.
  • The incidence of MACE was significantly reduced in the observation group versus the control group (P<0.05).

Conclusions:

  • Remote ischemic post-conditioning is a viable strategy to decrease MACE in AMI patients post-primary PCI.
  • The cardioprotective effect may be linked to the suppression of platelet activation, specifically CD62P expression.

Keywords:
acute myocardial infarctionmajor adverse cardiac eventsmaximum aggregation ratepercutaneous coronary interventionplatelet activationremote ischemic post-conditioning

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