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Updated: Feb 6, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
Published on: August 9, 2011
A hemicryptophane with a triple-stranded helical structure
Augustin Long1, Olivier Perraud2, Erwann Jeanneau3
1Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.
Abstract:
A hemicryptophane cage bearing amine and amide functions in its three linkers was synthesized in five steps. The X-ray molecular structure of the cage shows a triple-stranded helical arrangement of the linkers stabilized by intramolecular hydrogen bonds between amide and amine groups. The chirality of the cyclotriveratrylene unit controls the propeller arrangement of the three aromatic rings in the opposite part of the cage. 1H NMR studies suggest that this structure is retained in solution.
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