Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lagging Strand Synthesis01:59

Lagging Strand Synthesis

61.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.4K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

16.7K
16.7K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

14.8K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.8K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

4.4K
4.4K
Protein and Protein Structure02:15

Protein and Protein Structure

88.2K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
88.2K
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

4.5K
Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manganese(II) and Magnesium(II) Analogies in Iridium Hydride Coordination Chemistry.

Inorganic chemistry·2026
Same author

(<i>E</i>)-4-Chloro-2-[(4-hy-droxy-3-meth-oxy-benzyl-idene)amino]-phenol.

IUCrData·2026
Same author

Synthesis, Photophysical, and Chiroptical Properties of Optically Active BINOL-Boranil Enantiomers.

ACS omega·2026
Same author

A pH-Responsive Cu-Corrole-Based Cage That Reversibly Encapsulates Fullerene in a Shapeshifting Low-Symmetry Cavity.

Journal of the American Chemical Society·2026
Same author

(<i>E</i>)-1-(3,3'-Dimeth-oxy-4'-{[(<i>E</i>)-4-nitro-benzyl-idene]amino}-[1,1'-biphen-yl]-4-yl)-<i>N</i>-(4-nitro-phen-yl)methanimine.

IUCrData·2026
Same author

Electron-Deficient Confined Space: Synthesis and Recognition Properties of a Covalent Molecular Cage Built upon Naphthalene Diimides and Benzene Triimides.

Organic letters·2026
Same journal

Semisynthesis, characterisation, and antibacterial evaluation of a novel lecanoric acid-derived amide library.

Beilstein journal of organic chemistry·2026
Same journal

Synthesis and optical resolution of 4,5-diaminohomoadamantane: a promising scaffold for chiral ligands and bioactive compounds.

Beilstein journal of organic chemistry·2026
Same journal

Rh(III)-catalyzed chelation-assisted C-H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1-<i>a</i>]isoquinoline.

Beilstein journal of organic chemistry·2026
Same journal

<i>Z</i>-Selective semihydrogenation of alkynes via Ni/Lewis acid synergistic catalyzed system using DMF as hydrogen source and solvent.

Beilstein journal of organic chemistry·2026
Same journal

The role of spacer length and flexibility in peptide self-assembly.

Beilstein journal of organic chemistry·2026
Same journal

Novel macrocycles: from synthesis to supramolecular function.

Beilstein journal of organic chemistry·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
12:38

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

17.8K

A hemicryptophane with a triple-stranded helical structure.

Augustin Long1, Olivier Perraud2, Erwann Jeanneau3

  • 1Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.

Beilstein Journal of Organic Chemistry
|August 17, 2018
PubMed
Summary
This summary is machine-generated.

Researchers synthesized a novel hemicryptophane cage with amine and amide groups. Its triple-stranded helical structure, confirmed by X-ray crystallography and NMR, is maintained in solution.

Keywords:
CTVhemicryptophanesorganic cagestriple helical structure

More Related Videos

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.7K
Improving the Combustion Performance of a Hybrid Rocket Engine using a Novel Fuel Grain with a Nested Helical Structure
07:58

Improving the Combustion Performance of a Hybrid Rocket Engine using a Novel Fuel Grain with a Nested Helical Structure

Published on: January 18, 2021

6.5K

Related Experiment Videos

Last Updated: Feb 6, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
12:38

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

17.8K
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.7K
Improving the Combustion Performance of a Hybrid Rocket Engine using a Novel Fuel Grain with a Nested Helical Structure
07:58

Improving the Combustion Performance of a Hybrid Rocket Engine using a Novel Fuel Grain with a Nested Helical Structure

Published on: January 18, 2021

6.5K

Area of Science:

  • Supramolecular Chemistry
  • Organic Synthesis
  • Structural Chemistry

Background:

  • Hemicryptophane cages are molecular hosts with potential applications in molecular recognition and catalysis.
  • Designing cages with specific functional groups and predictable structures is crucial for tailored applications.

Purpose of the Study:

  • To synthesize a novel hemicryptophane cage incorporating amine and amide functionalities.
  • To elucidate the molecular structure and stability of the synthesized cage.

Main Methods:

  • Multi-step organic synthesis.
  • X-ray crystallography for solid-state structure determination.
  • Proton Nuclear Magnetic Resonance (1H NMR) spectroscopy for solution-state analysis.

Main Results:

  • Successful five-step synthesis of the hemicryptophane cage bearing amine and amide linkers.
  • X-ray structure revealed a triple-stranded helix stabilized by intramolecular hydrogen bonds.
  • The cage's propeller-like arrangement of aromatic rings is dictated by the cyclotriveratrylene unit's chirality.
  • 1H NMR data indicated the structural integrity of the cage in solution.

Conclusions:

  • A novel hemicryptophane cage with functional amine and amide groups was synthesized.
  • The cage exhibits a stable triple-stranded helical structure in both solid-state and solution.
  • The study demonstrates the control of molecular architecture through chiral units and intramolecular interactions.