Related Experiment Video
Updated: Feb 6, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
Circular RNAs as novel biomarkers with regulatory potency in human diseases
1The MOH Key Laboratory of Geriatrics, National Center of Gerontology, Beijing Hospital, 1 Dahua Road, DongCheng District, Beijing, PR China.
Abstract:
Circular RNAs (circRNAs) are a large class of noncoding RNAs characterized with closed loop structures without 3' and 5' polar ends. They can roughly be divided into exonic circRNAs, exon-intron circRNAs and circular intronic RNAs. CircRNAs are characterized with stability, prevalence, specificity and conservation, which arouse great interest in circRNAs as disease biomarkers. Their abilities to sponge to miRNAs, cis-regulate parent genes, bind to proteins and encode proteins endow circRNAs a critical role of regulation in eukaryotic cells. This concise review focuses on circRNAs as functional biomarkers and therapeutic targets in both tumor and nontumorous diseases.
Related Concept Videos
piRNA - Piwi-interacting RNAs
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Cis-regulatory Sequences
Cis-regulatory Sequences
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

