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Updated: Feb 6, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Clinical, Socioeconomic, and Psychosocial Factors Associated with Blood Pressure Control and Adherence: Results from
Daniela Sandoval1,2, Carolina Nazzal3, Tomás Romero4,5
1Department of Primary Care & Health Family, Faculty of Medicine, University of Chile, Santiago, Chile.
Insights
Blood pressure control was achieved in 63.1% of patients, but only 38.4% adhered to antihypertensive drug therapy. Factors like male sex, low income, and stress impacted control and adherence.
Area of Science:
- Cardiology
- Public Health
- Health Services Research
Background:
- Limited data exists on blood pressure (BP) control and antihypertensive medication adherence in developing nations.
- Understanding these factors is crucial for improving cardiovascular health outcomes.
Purpose of the Study:
- To investigate factors associated with blood pressure control and medication adherence among hypertensive patients in Chile.
- To identify key demographic, socioeconomic, and lifestyle predictors of treatment success.
Main Methods:
- A cross-sectional study involving 992 hypertensive patients in a Chilean Cardiovascular Health Program.
- Multivariate logistic regression analyzed associations between various factors (education, income, comorbidities, lifestyle, psychosocial status) and BP control/adherence.
Main Results:
- Blood pressure control (<140/90 mmHg) was achieved in 63.1% of patients; 38.4% were adherent to therapy.
- Uncontrolled BP linked to male sex, low income, high stress/depression, obesity, non-adherence, and sedentary lifestyle.
- Non-adherence associated with male sex, low income, high stress/depression, low social support, and uncontrolled BP.
Conclusions:
- Chilean hypertensive patients achieved BP control comparable to higher-income countries (63.1%).
- Both uncontrolled BP and low medication adherence (38.4%) were significantly associated with male sex, socioeconomic status, and psychosocial factors.
- Improved BP control and adherence were observed in diabetic patients.
Background:
Limited information exists on blood pressure (BP) control factors and adherence to antihypertensive drug therapy (Rx) in developing countries.
Methods:
Cross-sectional study in randomly selected 992 hypertensive patients under a Chilean national comprehensive Cardiovascular Health Program (CVHP). Association of education, income, diabetes, obesity, physical activity, psychosocial characteristics, smoking, and alcohol abuse with BP control and adherence were evaluated by multivariate logistic regression.
Results:
BP control (<140/90 mmHg) was achieved in 63.1% of patients, with 38.4% adherent to Rx. Uncontrolled BP significantly associated with male sex (OR: 1.73 [95% CI 1.35-2.22]), low family income, high emotional-stress-depression score, body mass index, no adherence (OR: 1.83 [95% CI 1.44 - 2.32]), multiple Rx, baseline systolic BP value, and sedentary life style. Males (OR: 1.54 [95% CI 1.23 - 1.93]), low family income, high emotional stress-depression score (OR: 2.15 [95% CI 1.68 - 2.76]), low social support, and uncontrolled BP (OR: 1.52 [95% CI 1.22-1.90]) associated with no adherence.
Conclusions:
Comparable BP control (63.1%) to higher-income societies was observed. Uncontrolled BP associated significantly to no adherence and both to male sex, socioeconomic, and psychosocial factors. Global low adherence (38.4%) and improved BP control and adherence in diabetics were noted.
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