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A study of serum Vitamin D level and its association with hypertension

Arnab Kar1, Sumana Datta2

  • 1Department of General Medicine, Malda Medical College, Malda, West Bengal, India.

Journal of Family Medicine and Primary Care
|August 17, 2018
PubMed

Insights

Low Vitamin D levels are linked to hypertension, particularly systolo-diastolic hypertension. This study found significantly lower Vitamin D in hypertensive patients compared to non-hypertensives, suggesting a potential role in cardiovascular health.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Emerging evidence links low Vitamin D levels to adverse cardiovascular (CV) effects.
  • While research exists on Vitamin D's role in CV disorders, studies are limited in certain regions.
  • This study investigates Vitamin D levels in relation to hypertension in North Bengal.

Purpose of the Study:

  • To examine the relationship between serum Vitamin D levels and hypertension.
  • To compare Vitamin D levels across different hypertension subtypes (ISH, IDH, SDH) and non-hypertensive individuals.

Main Methods:

  • A cross-sectional study involving 154 patients from a tertiary care hospital in North Bengal.
  • Serum Vitamin D levels were quantified using direct ELISA.
  • Blood pressure was measured, and statistical analyses were performed using SPSS.

Main Results:

  • Mean Vitamin D levels were significantly lower in the overall hypertensive group, isolated diastolic hypertension (IDH), and systolo-diastolic hypertension (SDH) groups compared to non-hypertensives (P < 0.05).
  • A trend towards lower Vitamin D was observed in isolated systolic hypertension (ISH) compared to non-hypertensives (P = 0.074).
  • A significant negative correlation was found between systolic blood pressure (SBP) and serum Vitamin D (P = 0.044), particularly in Vitamin D deficient/insufficient populations (P = 0.010).

Conclusions:

  • Systolo-diastolic hypertension is associated with significantly lower serum Vitamin D levels.
  • A trend suggests lower Vitamin D levels in isolated systolic hypertension compared to non-hypertensives, though not statistically significant.
  • The findings indicate a potential link between low Vitamin D and hypertension, warranting further investigation.
Abstract

Keywords:
HypertensionVitamin Disolated diastolic hypertensionisolated systolic hypertensionmean arterial pressuresystolo-diastolic hypertension

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