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Antibody-Drug Conjugates in Bladder Cancer

Panagiotis J Vlachostergios1, Christopher D Jakubowski1, Muhammad J Niaz1

  • 1Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

Bladder Cancer (Amsterdam, Netherlands)
|August 17, 2018
PubMed

Insights

Antibody-drug conjugates (ADCs) show promise for targeting urothelial carcinoma (UC) by utilizing specific cell surface antigens. Advanced ADCs like sacituzumab govitecan and enfortumab vedotin are in development, with new targets like HER2 emerging.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Urothelial carcinoma (UC) presents numerous cell surface antigens, creating therapeutic targets.
  • Antibody-drug conjugates (ADCs) leverage these antigens for targeted drug delivery.

Purpose of the Study:

  • To review the current landscape of ADCs in urothelial carcinoma treatment.
  • To highlight advanced ADCs and emerging targets for UC therapy.

Main Methods:

  • Review of existing literature on ADCs for urothelial carcinoma.
  • Identification of key ADCs and their targets in preclinical and clinical development.

Main Results:

  • Several ADCs are in advanced development for UC, including sacituzumab govitecan and enfortumab vedotin.
  • Emerging targets such as HER2 and FGF/FGFR axis show promise for novel ADC development.
  • Positive preclinical and early clinical data support further investigation.

Conclusions:

  • ADCs represent a promising therapeutic strategy for urothelial carcinoma.
  • Continued research focuses on enhancing ADC efficacy, reducing toxicity, and exploring combination therapies.
Keywords:
Antibody-drug conjugatebladder cancertargeted therapyurothelial carcinoma

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