[Voltage-gated sodium channels regulate the biological functions of macrophages]
Rong Zhou1, Meng Gou1, Rong Xiao2
1School of Life Sciences, Liaoning Normal University, Dalian 116081, China.
Abstract:
Voltage-gated sodium channels (VGSCs) play very important roles in the generation and conduction of action potential in the excitable cells. Recent studies have showed that VGSCs are also expressed in the macrophages and regulate a variety of biological functions, including phagocytosis, endosomal acidification, podosome formation, polarization, and antiviral responses, etc. This paper will review the roles of VGSCs in regulating the biological functions of macrophages and the underlying mechanisms, which would provide clues for the studies of the functions of VGSCs in the other immune cells.
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