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The effect of early puberty suppression on treatment options and outcomes in transgender patients.

Nature reviews. Urology·2020

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The Measurement and Treatment of Suppression in Amblyopia

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

Transgender medicine - puberty suppression.

Leonidas Panagiotakopoulos¹

¹Department of Pediatrics, Division of Pediatric Endocrinology, Emory University, 2nd floor, rm 456, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA. lpanagi@emory.edu.

Reviews in Endocrine & Metabolic Disorders

|August 17, 2018

Summary

This summary is machine-generated.

Puberty suppression using GnRH agonists is a reversible medical treatment for transgender youth, delaying unwanted secondary sexual characteristics and allowing time for gender dysphoria evaluation.

Keywords:

Bone health Endocrine transgender care GnRH agonists Puberty blockade Puberty suppression Transgender

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Area of Science:

Endocrinology
Pediatrics
Psychology

Background:

Puberty suppression is a reversible endocrine treatment for transgender youth.
It allows time for gender dysphoria evaluation and prevents unwanted secondary sexual characteristics.
This approach is modeled on treatments for precocious puberty, using GnRH agonists.

Purpose of the Study:

Review the rationale for puberty blockade in transgender children.
Discuss available methods for puberty suppression.
Examine potential adverse effects and future research directions.

Main Methods:

Review of existing literature on puberty suppression in transgender youth.
Analysis of GnRH agonist use in precocious puberty treatment.
Discussion of emerging data on adverse effects.

Main Results:

Puberty suppression provides crucial time for assessment and prevents distress from secondary sexual characteristics.
GnRH agonists are the core treatment, adapted from precocious puberty protocols.
Increasing use in younger transgender youth necessitates careful consideration of risks and benefits.

Conclusions:

Puberty suppression is a key intervention for transgender youth, offering diagnostic and therapeutic benefits.
Providers must weigh the advantages against emerging evidence of potential adverse effects.
Further research is needed to optimize treatment protocols and long-term outcomes.