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Updated: Feb 6, 2026

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model
Published on: September 1, 2023
Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators
Canan Kuş1, Ezgi Özer1, Yeşim Korkmaz2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100-Tandogan, Ankara, Turkey.
Background & Method:
In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05).
Conclusion:
uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).
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