Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic
Jace B King1,2, Jeffrey S Anderson1,2,3
1Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.
Human Brain Mapping
|August 17, 2018
Summary
We introduce sustained connectivity, a new brain activity metric, to measure synchronous activity duration. This reproducible and heritable trait shows sex and age differences and links to processing speed, offering new insights into brain dynamics.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Imaging
Background:
- Synchrony of brain activity over time, or functional connectivity, lacks temporal resolution.
- Existing methods do not fully capture the temporal dynamics of neural synchrony.
Purpose of the Study:
- To introduce and validate "sustained connectivity" as a novel metric for the duration of synchronous brain activity.
- To investigate the heritability, reproducibility, and demographic associations of sustained connectivity.
- To explore the relationship between sustained connectivity and cognitive functions like processing speed.
Main Methods:
- Utilized resting-state functional MRI (fMRI) data from 1,003 Human Connectome Project subjects.
- Introduced the width of cross-correlation curves between fMRI time series as the sustained connectivity metric.
- Correlated sustained connectivity with cognitive (processing speed, episodic memory) and demographic data.
Main Results:
- Sustained connectivity is a reproducible and heritable individual trait.
- It exhibits sex differences (more transient in females) and changes with age in early adulthood.
- Sustained connectivity in sensory regions correlates with processing speed, particularly in men.
- Traditional functional connectivity correlated with episodic memory, not processing speed.
- Sustained connectivity approximates individual hemodynamic response function (HRF) variability.
Conclusions:
- Sustained connectivity offers a complementary temporal dimension to functional connectivity analysis.
- It provides insights into individual differences in neural activity dynamics and cognitive performance.
- This metric holds potential for studying brain dynamics in clinical populations.
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