Heart failure with preserved ejection fraction in Asia

Area of Science:

• Cardiology
• Public Health
• Epidemiology

Background:

• Heart failure with preserved ejection fraction (HFpEF) is a significant global health concern.
• Limited data exists on HFpEF prevalence and characteristics across diverse Asian populations.

Purpose of the Study:

• To investigate the clinical profiles, echocardiographic features, and outcomes of HFpEF patients across different Asian regions.
• To identify regional variations in co-morbidities, cardiac geometry, and adverse events in HFpEF.

Main Methods:

• A prospective study involving 1204 HFpEF patients (left ventricular ejection fraction ≥50%) from 11 Asian regions.
• Data collection included clinical characteristics, co-morbidities, echocardiographic parameters, and 1-year outcomes.
• Patients were categorized into Northeast Asia, South Asia, and Southeast Asia groups.

Main Results:

• The study included 1204 HFpEF patients (mean age 68±12 years, 50% women).
• Common co-morbidities included hypertension (71%), anemia (57%), chronic kidney disease (50%), and diabetes (45%).
• Southeast Asian patients exhibited higher co-morbidity prevalence (except atrial fibrillation) and increased risk for adverse outcomes.

Conclusions:

• HFpEF in Asia impacts relatively young individuals with a substantial co-morbidity burden.
• Significant regional disparities exist in co-morbidities, cardiac remodeling, and HFpEF outcomes across Asia.
• Findings underscore the need for tailored public health strategies and inclusive global clinical trial designs for HFpEF.