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Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in
Carole Egron1, Laurence Roszyk2, Emmanuelle Rochette3
1Department of Pediatrics, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Insights
Serum soluble receptor for advanced glycation end-products (sRAGE) is lower in infants with acute bronchiolitis but does not predict disease severity or recurrent wheezing. Age adjustment is crucial for interpreting sRAGE levels in infants.
Area of Science:
- Pediatrics
- Pulmonology
- Biochemistry
Background:
- Acute bronchiolitis is a leading cause of infant respiratory distress.
- Soluble receptor for advanced glycation end-products (sRAGE) is a biomarker for pulmonary damage, with known roles in ARDS and asthma.
- The role of sRAGE in acute bronchiolitis requires further investigation.
Purpose of the Study:
- To assess the correlation between serum sRAGE levels and the clinical severity of acute bronchiolitis in infants.
- To analyze the relationship between sRAGE and short-term morbidity, viral causes, and the risk of recurrent wheezing.
Main Methods:
- Prospective, observational, and analytical study at Clermont-Ferrand University Hospital.
- Inclusion of 93 infants under 1 year old hospitalized for acute bronchiolitis.
- Measurement of serum sRAGE levels and correlation with Wainwright score, viral etiology, and 1-year follow-up for recurrent wheezing.
Main Results:
- Serum sRAGE levels were significantly lower in infants with acute bronchiolitis compared to controls (1101 pg/mL vs 2203 pg/mL, P < 0.001).
- No significant correlation was found between serum sRAGE levels and clinical severity scores, specific respiratory viruses, or recurrent wheezing at 1 year.
- Serum sRAGE levels showed a negative correlation with infant age (r = -0.45, P < 0.001).
Conclusions:
- Decreased serum sRAGE levels in acute bronchiolitis are not indicative of disease severity.
- Age-specific reference ranges are necessary for interpreting sRAGE levels in infants.
- Serum sRAGE is not a reliable predictor of recurrent wheezing in infants following acute bronchiolitis.
Introduction:
Acute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end-products (sRAGE) is a biomarker of pulmonary damage processes, with a diagnostic and a prognostic value in acute respiratory distress syndrome (ARDS). The RAGE pathway is also implicated in the pathogenesis of other respiratory diseases like asthma, but the value of sRAGE levels in acute bronchiolitis remains under-investigated.
Material And Methods:
A prospective, observational, and analytical study was conducted at Clermont-Ferrand University Hospital. The main objective was to evaluate the correlation between serum sRAGE and clinical severity of bronchiolitis in hospitalized infants aged <1 year. We analyzed correlations between serum sRAGE and Wainwright score, short-term morbidity attributable to bronchiolitis, causal viruses and risk for recurrent wheezing at 1 year.
Results:
The study included 93 infants. sRAGE levels were significantly lower in acute bronchiolitis patients (mean 1101 pg/mL) than in controls (2203 pg/mL, P < 0.001) but did not correlate with clinical severity. No correlation was found between serum sRAGE and severity score, respiratory viruses, and recurrent wheezing at 1 year. Serum sRAGE levels were negatively correlated with age (r = -0.45, P < 0.001).
Conclusion:
Serum sRAGE levels are decreased in acute bronchiolitis but not correlated with disease severity. sRAGE levels should be age-adjusted in infants. Serum sRAGE levels measured in the setting of acute bronchiolitis were not predictive of recurrent wheezing.
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