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Updated: Feb 6, 2026

Visualization of Biofilm Formation in Candida albicans Using an Automated Microfluidic Device
Published on: December 14, 2017
SDH2 is involved in proper hypha formation and virulence in Candida albicans
Shuang Bi1, Quan-Zhen Lv1, Tian-Tian Wang1
1School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Aim:
To investigate the role of SDH2 in Candida albicans filamentation and virulence.
Materials & Methods:
Caenorhabditis elegans and mouse candidiasis models were used to assess the virulence of a sdh2Δ/Δ mutant. Various hypha-inducing media were used to evaluate the hyphal development of C. albicans. DCFH-DA was used to measure intracellular Reactive Oxygen Species (ROS) levels.
Results:
The sdh2Δ/Δ mutant was avirulent in the C. elegans model, hypovirulent in a murine candidiasis model, and defective to form filaments both in vitro and in vivo. Intracellular ROS level increased in the sdh2Δ/Δ mutant, and the filamentation defects of sdh2Δ/Δ were rescued by decreasing intracellular ROS.
Conclusion:
SDH2 plays an important role in C. albicans filamentation and virulence probably through affecting intracellular ROS. [Formula: see text].
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