Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design

Bianca Santos1,2, Flavia Carmo1,2, Walkiria Schlindwein3

  • 1a Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro , Brazil.

Related Concept Videos

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
189
Properties of Continuous Functions01:29

Properties of Continuous Functions

Continuous functions exhibit smooth, uninterrupted behavior, and combining them through standard operations retains this continuity. If f and g are continuous at a point a, then the functions f+g, f-g, cf (where c is a constant), fg, and fg (provided g(a)a) are also continuous at a. This allows the construction of complex functions from simpler continuous parts without losing smoothness.Polynomials, which are expressions formed by sums of powers of x with constant coefficients, are continuous...
187
Properties of Electric Field Lines01:25

Properties of Electric Field Lines

The definition of electric field lines greatly eases the visualization of electric fields, a vector field, especially in the presence of many charges. The one-to-one correspondence between the electric field and the electric field lines necessitates that the field lines follow some rules.
For one, the electric field of a positive charge must originate from it. That is because its electric field points away from it. Moreover, since the magnitude of the field asymptotes to zero at infinity, the...
9.6K
Information Processing Approach01:30

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
586
High-Performance Liquid Chromatography: Elution Process01:05

High-Performance Liquid Chromatography: Elution Process

In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
1.6K
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
322