Related Experiment Video
Updated: Feb 6, 2026

Twin-Screw Extrusion Process to Produce Renewable Fiberboards
Published on: January 27, 2021
Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design
Bianca Santos1,2, Flavia Carmo1,2, Walkiria Schlindwein3
1a Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro , Brazil.
Abstract:
Screw feeder performance is a critical aspect in continuous manufacturing processes. Pharmaceutical excipients, such as mannitol, microcrystalline cellulose, lactose monohydrate, and anhydrous dibasic calcium phosphate can present problems in ensuring a continuous stable feed rate due to their sub-optimal flow properties. In alignment with Quality by Design (QbD) goals, the aim of this work was to identify and explain critical sources of variability of some powder excipients delivery by screw feeding, in particular to continuous processing lines. Pharmaceutical excipients with a wide range of material properties were selected, and the impact of their flow and density properties on screw feeder performance was investigated. The analysis of the powder conveying by the screws was performed at different hopper fills and different screw speeds. A multivariable model involving bulk density (CBD) and parameters from FT4 dynamic downwards testing (SI) and dynamic upwards testing (SE) explained 95.7% of excipients feed rates (p < .001). The study gathers valuable information about the screw feeder performance and input materials properties that can help process understanding and QbD-based development of solid dosage forms in continuous processing lines.
More Related Videos
09:56Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
07:00Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
Published on: August 11, 2017
Related Concept Videos
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
Properties of Continuous Functions
Properties of Electric Field Lines
For one, the electric field of a positive charge must originate from it. That is because its electric field points away from it. Moreover, since the magnitude of the field asymptotes to zero at infinity, the...
Information Processing Approach
High-Performance Liquid Chromatography: Elution Process
Dosage Regimens: Designs and Approaches