Related Experiment Video
Updated: Feb 6, 2026
17:50
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
Published on: July 4, 2007
13.0K
Host Genetic Polymorphisms Influencing Susceptibility to Dengue
Sudheer Gupta1, Ankita Agarwal1, Debasis Biswas1
1Regional Virology Laboratory, Department of Microbiology, All India Institute of Medical Sciences Bhopal , Bhopal, India .
DNA and Cell Biology
|August 17, 2018
Summary
Host genetic factors influence dengue infection severity. This review updates knowledge on genetic polymorphisms affecting dengue susceptibility, categorized by immune system association, to understand disease pathogenesis.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- Dengue is a global pandemic-prone viral disease affecting over 100 countries, putting half the world's population at risk.
- While often presenting as mild fever, dengue can cause severe, life-threatening conditions like dengue hemorrhagic fever and dengue shock syndrome in about 25% of infected individuals.
- The complex pathogenesis of differential dengue outcomes involves virus, vector, and host factors, with host genetic influences being crucial but not fully understood.
Purpose of the Study:
- To provide an updated review of host genetic polymorphisms associated with dengue susceptibility.
- To categorize these genetic factors based on their association with different components of the immune system.
- To enhance understanding of the genetic underpinnings of dengue pathogenesis and differential disease outcomes.
Main Methods:
- Literature review of studies reporting host genetic polymorphisms and their association with dengue infection.
- Categorization of identified genetic factors based on their role within the innate and adaptive immune systems.
- Synthesis of current knowledge on how these genetic variations impact dengue susceptibility and disease severity.
Main Results:
- Numerous host genetic polymorphisms have been identified that influence susceptibility to dengue virus infection.
- These genetic factors are associated with various arms of the immune system, including innate immunity (e.g., pattern recognition receptors) and adaptive immunity (e.g., cytokine signaling pathways).
- Specific polymorphisms correlate with increased or decreased risk of developing severe dengue manifestations.
Conclusions:
- Host genetics play a significant role in determining dengue infection outcomes.
- Understanding these genetic determinants is essential for elucidating dengue pathogenesis.
- Further research into host genetic factors may offer insights for novel prevention and treatment strategies against dengue.
Keywords:
denguedengue hemorrhagic feverdengue shock syndromedengue susceptibilitygenetic polymorphismMore Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
12.2K
07:00A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
10.4K
Related Concept Videos
02:16Genetics of Speciation
21.7K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.7K
02:59Animal Mitochondrial Genetics
9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
01:31Magnetic Susceptibility and Permeability
2.4K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
02:18Types of Genetic Transfer Between Organisms
30.9K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.9K
01:05Single Nucleotide Polymorphisms-SNPs
18.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.4K
01:25What is Population Genetics?
64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K