Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Molecular Models

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.

Sternberg's Triangular Theory of Love

Sternberg's Triangular Theory of Love

We typically love the people with whom we form relationships, but the type of love we have for our family, friends, and lovers differs. Robert Sternberg (1986) proposed that there are three components of love: intimacy, passion, and commitment. These three components form a triangle that defines multiple types of love: this is known as Sternberg’s triangular theory of love. Intimacy is the sharing of details and intimate thoughts and emotions. Passion is the physical attraction—the...

Ecological Niches

Ecological Niches

All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.

Subatomic Particles

Subatomic Particles

Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.

Position-effect Variegation

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.

Epistasis

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Posterior lumbar facet arthroplasty versus fusion for the treatment of spondylolisthesis: 3-year results from the Total Posterior Spine System investigational device exemption study.

Neurosurgical focus·2026

Same author

Preliminary Reliability and Validity of SynapTrack, a Smartphone-Based Digital Biomarker Platform for Remote Assessment of Cervical Spondylotic Myelopathy.

medRxiv : the preprint server for health sciences·2026

Same author

Technological Lag of Digitization for Patient Image Transfer.

Academic radiology·2026

Same author

Definitions and Diagnostic Criteria of Lumbar Spine Instability: A Systematic Review.

The spine journal : official journal of the North American Spine Society·2026

Same author

Validation of Gait Tasks in SynapTrack Mobile App for Cervical Spondylotic Myelopathy.

medRxiv : the preprint server for health sciences·2026

Same author

Association of Physical Activity and Obesity With the Risk of Degenerative Cervical Myelopathy.

Neurosurgery·2026

Search research articles

Related Experiment Video

Updated: Jan 23, 2026

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Published on: January 25, 2021

A Tribute to Dr Robert J. White.

Min Lang^1,2,3, John Tsiang^1,3, Nina Z Moore^1,3

¹Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

|August 17, 2018

Summary

Neurosurgeon Robert J. White pioneered cephalic exchange and brain isolation in monkeys. His extensive research in neurosurgery, neuroanesthesia, and bioethics earned him Nobel Prize nominations.

Keywords:

Head transplant History Metrohealth Hospital Robert White

More Related Videos

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus

Published on: October 3, 2014

Related Experiment Videos

Last Updated: Jan 23, 2026

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Published on: January 25, 2021

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus

Published on: October 3, 2014

Area of Science:

Neurosurgery
Neuroscience
Bioethics

Background:

Robert J. White, a pioneering neurosurgeon, trained at leading institutions including the University of Minnesota and Harvard University.
He became the first Chief of Neurosurgery at Metrohealth Hospital in Cleveland, Ohio.
White's early career included significant contributions to neuroanesthesia and bioethics.

Discussion:

White's groundbreaking work involved the first successful "cephalic exchange" on monkeys in 1971.
His team achieved the isolation of the monkey brain while retaining biological activity.
He also made significant advancements in spinal cord cooling and hypothermia techniques.

Key Insights:

White's research and surgical innovations pushed the boundaries of neurosurgical research.
He performed over 10,000 brain operations and published over 1,000 articles.
Twice nominated for the Nobel Prize in Physiology or Medicine, he is one of only three neurosurgeons to receive this honor.

Outlook:

White's legacy includes not only his surgical achievements but also his advocacy for animal research and his role as an advisor to religious leaders.
His work continues to influence the fields of neurosurgery, neuroanesthesia, and bioethical considerations in medical research.