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Updated: Feb 6, 2026
Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
[Pseudomyxoma peritonei : a cause of ascites that should not be underestimated]
T Sinatra1, C Coimbra Marques2
1Faculté de Médecine, Université de Liège, Belgique.
Abstract:
Pseudomyxoma peritonei (PMP) is a rare condition that refers to a clinical syndrome resulting from the accumulation of mucin in the peritoneal cavity. It results from the intraperitoneal rupture of a mucinous epithelial neoplasm which is classically appendiceal. The prognosis of a limited appendiceal tumor is favourable. Nevertheless, in the case of peritoneal dissemination, the prognosis could be different according to the histological type and therapeutic management. We report the case of a 71-year-old female patient who developed a pseudomyxoma peritonei originating from an appendiceal adenocarcinoma.
Insights
Pseudomyxoma peritonei (PMP) is a rare condition caused by mucin accumulation in the abdomen, often from appendiceal tumors. This case highlights PMP from appendiceal adenocarcinoma, emphasizing varied prognoses with peritoneal spread.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by peritoneal mucin accumulation.
- It typically arises from the intraperitoneal rupture of a mucinous epithelial neoplasm, most commonly appendiceal.
- While limited appendiceal tumors have a favorable prognosis, peritoneal dissemination alters outcomes based on histology and treatment.
Observation:
- A case report of a 71-year-old female patient presenting with pseudomyxoma peritonei is described.
- The PMP in this patient originated from an appendiceal adenocarcinoma.
- This presentation underscores the potential for appendiceal adenocarcinoma to cause extensive peritoneal disease.
Findings:
- Appendiceal adenocarcinoma can lead to pseudomyxoma peritonei with peritoneal dissemination.
- The histological subtype and therapeutic approach significantly influence the prognosis of PMP.
- This case illustrates a specific instance of PMP originating from a malignant appendiceal neoplasm.
Implications:
- Understanding the origin and behavior of appendiceal neoplasms is crucial for managing PMP.
- Accurate histological typing and tailored therapeutic strategies are essential for improving patient outcomes in PMP.
- This case contributes to the literature on rare gastrointestinal malignancies and their peritoneal manifestations.
