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Updated: Feb 6, 2026

Tissue Processing and Isolation of Primary Fibroblasts from the Human Vagina
Published on: November 22, 2024
[Primary malignant melanoma of vagina]
M Daix1, P Dillies2, A Gueuning3
1Service de Gynécologie-Obstétrique, CHC Saint-Vincent, Rocourt (Liège), Belgique.
Abstract:
The primary vaginal melanoma is a rare aggressive tumour with a poor prognosis. The average age at diagnosis is 60, and there are no known risk factors. The establishment of a classification system and treatment protocols are made difficult because there are so few cases. The 5-year survival rate is estimated at no more than ten per cent. We report a case of an inoperable primary vaginal melanoma in a 58-year old woman. There were metastatic lymph nodes in the lumbo-aortic region, but no extension to bone or viscera. She was treated with nivolumab as monotherapy. Clinical and radiological evolution were both favourable, and the treatment was well tolerated.
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