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Updated: Feb 6, 2026

Experimental Implementation of a New Composite Fabrication Method: Exposing Bare Fibers on the Composite Surface by the Soft Layer Method
Published on: October 6, 2017
Histopathological differences of experimental aneurysms treated with bare platinum, fibered, and bioactive coils
Yoko Usami1, Naoki Hirokawa1, Masato Saitoh1
1a Department of Radiology , Sapporo Medical University , Sapporo , Japan.
Purpose:
To evaluate the histopathological features of experimental aneurysms embolized with bare platinum, fibered, and bioactive coils.
Material And Methods:
Twelve experimental aneurysms were constructed in three swine. The aneurysms were divided into four groups and were embolized using a bare platinum coil alone (P group, n = 2), a bioactive coil alone (B group, n = 2), a combination of fibered and bare platinum coils (F/P group, n = 4) and a combination of fibered and bioactive coils (F/B group, n = 4). Histopathological data for all aneurysms recorded at 63 days were analyzed in terms of neointima formation, fibrosis, foreign-body giant-cell infiltration, and organization.
Results:
Fibrosis was significantly greater in group B compared with that in group F/P (p = .02). Inflammation with foreign-body giant-cell infiltration was significantly greater in groups F/P and F/B compared with that in groups P and B (p = .007).
Conclusion:
The present study revealed that the embolic effect of fibered coils was not a thrombus but instead was a foreign-body response in the chronic phase.
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