Related Experiment Video
Updated: Feb 6, 2026
04:09
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
1.3K
Polycythemia vera: diagnosis, clinical course, and current management
Turkish Journal of Medical Sciences
|August 17, 2018
Summary
Recent advances in polycythemia vera (PV) diagnosis and management include JAK2 mutation discovery and JAK inhibitors like ruxolitinib. Current PV treatment focuses on reducing thromboembolic risk.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Polycythemia vera (PV) management has significantly evolved over the past two decades.
- The discovery of Janus kinase (JAK) 2 mutations revolutionized PV diagnosis and treatment strategies.
- Understanding JAK-STAT signaling pathways is crucial for Philadelphia-negative myeloproliferative neoplasms.
Purpose of the Study:
- To review the clinical aspects of polycythemia vera.
- To propose a management algorithm for PV based on current evidence.
- To highlight unresolved questions and unmet needs in PV diagnosis and management.
Main Methods:
- Review of recent developments in PV diagnosis and treatment.
- Analysis of the role of JAK2 mutations and JAK inhibitors.
- Evaluation of international collaborations in describing disease characteristics and prognosis.
Main Results:
- JAK2 molecular testing is now essential for PV diagnosis.
- Ruxolitinib, a JAK1/JAK2 inhibitor, is approved for specific PV patient populations.
- Disease burden and prognosis can be quantified, but management still relies on thromboembolic risk assessment.
Conclusions:
- Despite advances, PV management remains focused on mitigating thromboembolic risk.
- International consensus provides guidance on diagnosis, risk stratification, and drug selection.
- Further research is needed to address remaining challenges in PV care.
Related Concept Videos
01:28Esophageal Perforation-II: Clinical Manifestations and Management
738
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
738
01:21Barrett Esophagus-II: Clinical Manifestations and Management
1.1K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.1K
01:28Esophageal Varices-II: Clinical Features and Management
591
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
591
01:23Gastritis III: Clinical Manifestations and Management
1.3K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.3K
01:26Esophageal Strictures-II: Clinical Features and Management
672
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
672
01:30Acute Pancreatitis II: Clinical Manifestations and Management
878
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
878