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Updated: Feb 6, 2026

In Situ Labeling of Mitochondrial DNA Replication in Drosophila Adult Ovaries by EdU Staining
Published on: October 15, 2016
A mitochondrial DNA D loop insertion detected almost exclusively in non-replicating tissues with maternal inheritance
Mehul A Sharma1, Ja Young J Lee1, Andrea Tam1
1Department of Pathology and Laboratory Medicine, The University of British Columbia, Canada.
Abstract:
Muscle biopsy identified a possibly pathogenic, mitochondrial DNA D-loop insertion, in each of 5 family members from two generations, that was otherwise undetectable in most other tissues. The tissue specific regulation of heteroplasmy is reflected in an age related increase in muscle heteroplasmy level, across the pedigree. This latter finding is in keeping with previous reports (e.g. T408A, C16327) but differs in having a very high muscle heteroplasmy level, and appears maternally transmitted.
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