Molecular size of alpha 1- and beta-adrenoceptors in rat brain cortex as determined by a radiation inactivation...

Frozen whole rat cerebral cortex was exposed to 10 MeV electrons from a linear accelerator. Based on the theory of target size analysis, the in situ molecular weight of alpha 1-adrenoceptors (labelled by [3H]prazosin) and beta-adrenoceptors (labelled by [3H]dihydroalprenolol) was 57 800 daltons and 42 600 daltons, respectively.