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Updated: Feb 6, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Honokiol: An anticancer lignan.

Abdur Rauf¹, Seema Patel², Muhammad Imran³

¹Department of Chemistry, University of Swabi, Anbar-23561, Khyber Pakhtunkhwa, Pakistan.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

|August 17, 2018

Summary

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This summary is machine-generated.

Honokiol, a natural lignan, shows significant antitumor activity by inhibiting cancer cell proliferation and survival. This review details its mechanisms and potential in cancer management.

Area of Science:

Natural Products Chemistry
Cancer Biology
Pharmacology

Background:

Honokiol is a lignan with demonstrated antitumor properties against various human cancer cell lines.
It inhibits cancer cell proliferation, invasion, and survival in both in vitro and in vivo models.
Honokiol exerts its effects by interfering with key cellular signaling pathways.

Purpose of the Study:

To review and discuss published data on honokiol's efficacy in cancer treatment.
To explore honokiol's mechanisms of action against diverse cancer types.
To highlight the potential and challenges of honokiol in clinical cancer management.

Main Methods:

Literature review of studies on honokiol's anticancer effects.
Analysis of in vitro and in vivo data on cancer cell lines and animal models.

Keywords:

Breast cancer Honokiol Ovarian and lung cancer Prostate cancer Signaling pathways

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Discussion of signaling pathways modulated by honokiol.

Main Results:

Honokiol downregulates pluripotency factors, mammosphere formation, P-glycoprotein, CXCR4, c-FLIP, SRC-3, Twist1, HDACs, and H3K27 methyltransferase.
It upregulates BMP7 and Bax protein expression.
Honokiol modulates critical pathways including NF-κB, STAT3, m-TOR, EGFR, and SHH.

Conclusions:

Honokiol exhibits broad anticancer functions by targeting multiple molecular pathways.
It enhances the efficacy of conventional anticancer drugs and radiation therapy.
Derivatives of honokiol show promise for cancer control, warranting further investigation.