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Updated: Feb 6, 2026
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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Spontaneous Keloids: A Literature Review
Dermatology (Basel, Switzerland)
|August 17, 2018
Summary
Spontaneous keloids, which arise without clear trauma, are often linked to genetic syndromes. Further research is needed to understand their pathogenesis and clinical diagnosis.
Area of Science:
- Dermatology
- Genetics
- Pathology
Background:
- Keloids are benign fibroproliferative tumors extending beyond original wounds.
- Spontaneous keloids develop without a significant history of trauma.
- Multiple cases of spontaneous keloids are documented in medical literature.
Purpose of the Study:
- To review and summarize reported cases of spontaneous keloids.
- To categorize spontaneous keloids based on associated medical conditions.
- To explore potential underlying causes of spontaneous keloid formation.
Main Methods:
- Comprehensive literature review of published cases and case series.
- Searches conducted in PubMed and MEDLINE databases.
- Inclusion of all English-language publications from May 1955 to February 2018.
Main Results:
- Spontaneous keloids are frequently associated with genetic syndromes (e.g., Rubinstein-Taybi, Dubowitz, Noonan).
- Reported associations include specific myopathies and dystrophies.
- Cases also noted in atopic individuals and healthy patients.
Conclusions:
- Clinical diagnosis of spontaneous keloids relies on patient history.
- Confirmation can be challenging due to potential triggers like minor injury or inflammation.
- Genetic factors are implicated in the pathogenesis of spontaneous keloids.
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