Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lagging Strand Synthesis

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...

PCR

PCR

Replication in Prokaryotes

Replication in Prokaryotes

Telomeres and Telomerase

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...

The Replisome

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...

Replication in Eukaryotes

Replication in Eukaryotes

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advanced glucose control strategies leveraging Raman spectroscopy for optimized mammalian cell culture manufacturing.

Biotechnology progress·2026

Same author

Firm, Yellow, and Now Fluid-Filled!

Clinical and experimental dermatology·2026

Same author

Turning struggles into strengths: A qualitative exploration of academic difficulty in medical school.

Medical teacher·2026

Same author

Mecp2 deficiency impairs microscale cortical network topology and dynamics in a Rett syndrome mouse model.

bioRxiv : the preprint server for biology·2025

Same author

Mediastinal staging of nonsmall cell lung cancer: what's new?

Breathe (Sheffield, England)·2025

Same author

Population density drives increased parasitism via greater exposure and reduced resource availability in wild red deer.

Parasitology·2025

Search research articles

Related Experiment Video

Updated: Feb 6, 2026

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Published on: December 23, 2022

A general practitioner primer on groin hernias.

Richard Turner¹

¹MBBS (Hons), BMedSc, FRACS, PhD, Professor of Surgery, University of Tasmania School of Medicine; Director, Hobart Clinical School; Consultant General Surgeon, Royal Hobart Hospital, Hobart. richard.turner@utas.edu.au.

Australian Journal of General Practice

|August 18, 2018

Summary

This summary is machine-generated.

General practitioners can improve patient care for groin hernias by understanding anatomy and management. This guide offers key insights for primary care settings to enhance the patient journey.

More Related Videos

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Published on: September 11, 2021

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Published on: October 2, 2017

Related Experiment Videos

Last Updated: Feb 6, 2026

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Published on: December 23, 2022

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Published on: September 11, 2021

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Published on: October 2, 2017

Area of Science:

General Practice
Surgical Conditions

Background:

Groin hernias are common in primary care, particularly affecting adult males.
While not typically life-threatening, groin hernias can cause significant morbidity and impact earning capacity.

Purpose of the Study:

To enhance understanding of groin hernias for general practitioners.
To provide current best practice information for managing groin hernias in primary care.

Main Methods:

Review of relevant medical literature.
Incorporation of clinical experience.

Main Results:

Key management principles for groin hernias identified.
Information tailored for the primary care setting.

Conclusions:

General practitioners require sound knowledge of anatomy, clinical findings, and management.
Effective management in primary care can improve the patient journey for groin hernias.