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Related Experiment Video

Updated: Feb 6, 2026

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography
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Dynamic arterial elastance measured by uncalibrated pulse contour analysis predicts arterial-pressure response to a

S Bar1, F Leviel1, O Abou Arab1

  • 1Department of Anaesthesiology and Critical Care Medicine, Amiens University Hospital, F-80054 Amiens, France.

British Journal of Anaesthesia
|August 18, 2018
PubMed
Summary
This summary is machine-generated.

Dynamic arterial elastance (Ea_dyn) effectively predicts arterial pressure drops when norepinephrine (NE) dosage is reduced. This study shows Ea_dyn measured by uncalibrated pulse contour analysis (UPCA) is a reliable indicator of vascular tone.

Keywords:
hemodynamicsnorepinephrinevasoplegia

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Area of Science:

  • Cardiovascular Physiology
  • Critical Care Medicine
  • Hemodynamics

Background:

  • Dynamic arterial elastance (Ea_dyn) is a proposed indicator of vascular tone.
  • Ea_dyn predicts arterial pressure decrease with norepinephrine (NE) changes.
  • Uncalibrated pulse contour analysis (UPCA) is a method for measuring Ea_dyn.

Purpose of the Study:

  • To determine if Ea_dyn measured by UPCA can predict arterial pressure decrease upon reduction of NE dosage.
  • To assess the utility of Ea_dyn as a functional measure of arterial tone.

Main Methods:

  • Prospective study in an intensive care unit.
  • Included patients with vasoplegic syndrome undergoing NE dosage reduction.
  • Measured hemodynamic and UPCA values before and after NE dosage decrease.
  • Defined responders as those with >10% decrease in mean arterial pressure (MAP).

Main Results:

  • Ea_dyn correlated with systolic arterial pressure (SAP), diastolic arterial pressure, MAP, heart rate, and cardiac output.
  • Baseline Ea_dyn correlated with MAP and SAP changes.
  • Ea_dyn predicted arterial pressure decrease with an AUC of 0.84.
  • Optimal Ea_dyn cut-off for prediction was 0.90.

Conclusions:

  • Ea_dyn measured by UPCA reliably predicts arterial pressure response to NE dosage reduction.
  • Ea_dyn offers an easy-to-use functional assessment of arterial tone.
  • This method is monitor-independent for assessing arterial tone.