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Pertussis: The Whooping Cough

Van Tuong Ngoc Nguyen1, Lauren Simon1

  • 1Department of Family Medicine, Loma Linda University, 1200 California Street, Suite 240, Redlands, CA 92374, USA.

Primary Care
|August 18, 2018
PubMed

Insights

Early diagnosis and treatment of pertussis, caused by Bordetella pertussis, with macrolide antibiotics like azithromycin can prevent severe infant complications. Prompt intervention also reduces disease transmission.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Bordetella pertussis causes severe infant complications.
  • Pertussis is highly contagious.

Purpose of the Study:

  • To highlight the importance of early pertussis diagnosis and treatment.
  • To emphasize macrolide antibiotics for mitigating complications and spread.

Main Methods:

  • Literature review on Bordetella pertussis pathogenesis and treatment.
  • Analysis of clinical outcomes associated with early macrolide antibiotic use.

Main Results:

  • Early azithromycin treatment before the paroxysmal stage is effective.
  • Macrolides reduce pertussis severity and transmission.

Conclusions:

  • Prompt diagnosis and macrolide treatment are crucial for infants with pertussis.
  • Early intervention significantly improves outcomes and controls outbreaks.

Keywords:
Bordetella pertussisParoxysmal coughTdap and DTaP vaccineWhooping cough

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