Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adhesion01:14

Adhesion

44.5K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
44.5K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

4.0K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
4.0K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

3.9K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.9K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.4K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.4K
What is the Cell Cycle?00:56

What is the Cell Cycle?

10.6K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
10.6K
What is the Cell Cycle?01:04

What is the Cell Cycle?

243.3K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
243.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors.

bioRxiv : the preprint server for biology·2026
Same author

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.

The Journal of cell biology·2026
Same author

Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.

Nature neuroscience·2025
Same author

A switch in collagen expression regulates cessation of distal tip cell migration in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2025
Same author

Twinfilin modulates tissue contractility through uncapping of capping protein in C. elegans.

Development (Cambridge, England)·2025
Same author

Twinfilin is a potent uncapper of actin capping protein and modulates actomyosin contractility in the <i>C. elegans</i> spermatheca.

bioRxiv : the preprint server for biology·2025
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Use of Drosophila S2 Cells for Live Imaging of Cell Division
06:17

Use of Drosophila S2 Cells for Live Imaging of Cell Division

Published on: August 23, 2019

9.0K

Cell cycle pacemaker keeps adhesion in step with division.

Ronen Zaidel-Bar1

  • 1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel zaidelbar@tauex.tau.ac.il.

The Journal of Cell Biology
|August 18, 2018
PubMed
Summary
This summary is machine-generated.

Cell division requires cell rounding, but cell cycle regulation of detachment remains unclear. A new study reveals Cyclin-Dependent Kinase 1 (CDK1) maintains cell adhesion during interphase, with its loss in G2 triggering detachment.

More Related Videos

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning
07:38

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning

Published on: April 30, 2021

3.8K
Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

3.6K

Related Experiment Videos

Last Updated: Feb 6, 2026

Use of Drosophila S2 Cells for Live Imaging of Cell Division
06:17

Use of Drosophila S2 Cells for Live Imaging of Cell Division

Published on: August 23, 2019

9.0K
Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning
07:38

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning

Published on: April 30, 2021

3.8K
Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

3.6K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular adhesion is crucial for tissue integrity and cell behavior.
  • Cell rounding precedes cell division, but the underlying regulatory mechanisms, especially cell cycle control of detachment, are not fully understood.

Purpose of the Study:

  • To investigate the role of the cell cycle in regulating cell adhesion and detachment.
  • To identify key molecular players involved in cell cycle-dependent adhesion regulation.

Main Methods:

  • Phosphorylation analysis of integrin adhesome proteins.
  • Investigating the function of Cyclin-Dependent Kinase 1 (CDK1) in cell adhesion.
  • Studying the impact of CDK1 activity on cell detachment during the cell cycle.

Main Results:

  • The kinase CDK1 maintains cell adhesion during interphase by phosphorylating integrin adhesome proteins.
  • Formin FMNL2 is identified as one of the CDK1 targets involved in maintaining adhesion.
  • Loss of CDK1's adhesive function in the G2 phase of the cell cycle triggers adhesion disassembly.

Conclusions:

  • CDK1 plays a critical role in maintaining cell adhesion throughout interphase via phosphorylation of key adhesome proteins.
  • The regulation of cell adhesion by CDK1 is essential for proper cell cycle progression and detachment before division.