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Respiratory syncytial virüs infections in neonates and infants

Yıldız Perk1, Mine Özdil1

  • 1Department of Pediatrics, Division of Neonatology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.

Turk Pediatri Arsivi
|August 18, 2018
PubMed

Insights

Respiratory syncytial virus (RSV) causes severe infant respiratory infections, leading to hospitalizations and mortality. Currently, immunoprophylaxis with palivizumab is the only preventive measure for high-risk infants.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of infant respiratory tract infections.
  • It leads to high hospitalization and mortality rates in young children, being a leading cause of bronchiolitis and pneumonia.
  • RSV is also linked to recurrent wheezing and pediatric asthma.

Purpose of the Study:

  • To highlight the severity and impact of RSV infections in infants.
  • To underscore the lack of specific treatments and vaccines for RSV.
  • To emphasize the role of immunoprophylaxis in managing severe RSV cases.

Main Methods:

  • Review of existing literature on RSV epidemiology and clinical impact.
  • Analysis of current therapeutic and preventive strategies for RSV.
  • Identification of high-risk populations susceptible to severe RSV infection.

Main Results:

  • RSV is a significant global health concern, particularly for infants under two.
  • High-risk infants (prematurity, congenital heart disease, immune deficiencies) face severe outcomes.
  • No specific antiviral treatment or vaccine is currently available for RSV.

Conclusions:

  • Severe RSV cases necessitate supportive care like oxygen and hydration.
  • Palivizumab immunoprophylaxis remains the sole option for reducing severe RSV morbidity in high-risk infants.
  • Further research is needed for effective RSV prevention and treatment strategies.

Keywords:
Bronchiolitisinfantnewbornpalivizumabrespiratory syncytial virus

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