Related Experiment Video

Updated: Feb 6, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.0K

Is there any association between adenoid biofilm and upper airway infections in pediatric patients?

Gholamreza Bayazian1, Shirin Sayyahfar1, Mahdi Safdarian1

  • 1Department of Ear, Nose, and Throat, Head and Neck Research center, Iran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Tehran, Iran.

Turk Pediatri Arsivi
|August 18, 2018
PubMed

Insights

The extent of adenoid biofilms in children is linked to frequent upper airway infections. Biofilms on adenoid tissue may act as reservoirs for chronic inflammation and recurrent infections.

Area of Science:

  • Otorhinolaryngology
  • Microbiology
  • Pediatric Health

Background:

  • Recurrent upper airway infections (UAIs) are common in children.
  • Adenoid hypertrophy often leads to airway obstruction and sleep-disordered breathing.
  • The role of microbial biofilms in chronic adenoid-related issues is increasingly recognized.

Purpose of the Study:

  • To investigate the association between adenoid biofilms and the frequency of UAIs in children with upper airway obstruction.
  • To quantify the extent of biofilm formation on adenoid tissue.

Main Methods:

  • A cross-sectional study involving 57 pediatric patients undergoing adenoidectomy for obstructive sleep apnea.
  • Adenoid tissue samples were analyzed using environmental scanning electron microscopy to assess biofilm extent.
  • Image analysis software confirmed biofilm presence and grading.

Main Results:

  • Biofilm structures were detected in 100% of adenoid samples.
  • A statistically significant correlation was found between the extent of biofilm grading and the frequency of UAIs (p<0.001).
  • No significant correlation was observed between biofilm extent, sex, or adenoid size.

Conclusions:

  • The extent of adenoid biofilm significantly correlates with the rate of upper airway infections in children.
  • Adenoid biofilms may serve as reservoirs for microorganisms, contributing to chronic inflammation and recurrent infections.
  • This finding highlights the potential impact of biofilms on pediatric airway health.
Abstract

Keywords:
Adenoidectomybiofilmsinfectionobstructive sleep apnea

More Related Videos

Co-culture Models of Pseudomonas aeruginosa Biofilms Grown on Live Human Airway Cells11:21

Co-culture Models of Pseudomonas aeruginosa Biofilms Grown on Live Human Airway Cells

Published on: October 6, 2010

22.8K
Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.6K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
314
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
237
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
305
Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1.4K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K