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Benign transient hyperphosphatasemia in an infant during zinc supplementation
Ayça Bilge Sönmez1, İlter Arifoğlu2, Ahmet Yıldırım1
1Department of Pediatrics, Trakya University School of Medicine, Edirne, Turkey.
Insights
Benign transient hyperphosphatasemia, a biochemical disorder causing high alkaline phosphatase, is often found incidentally in children. Prompt recognition by pediatricians prevents unnecessary medical tests for this self-resolving condition.
Area of Science:
- Biochemistry
- Pediatrics
- Clinical Diagnostics
Background:
- Benign transient hyperphosphatasemia is a biochemical disorder characterized by elevated alkaline phosphatase (ALP) levels.
- It is typically detected incidentally in infants and children without evidence of bone or liver disease.
- The condition is transient and resolves spontaneously over a short period.
Observation:
- This case report details an infant diagnosed with benign transient hyperphosphatasemia.
- The infant presented with elevated alkaline phosphatase levels during zinc supplementation.
- Clinical and laboratory findings supported the diagnosis.
Findings:
- The infant's elevated alkaline phosphatase levels were attributed to benign transient hyperphosphatasemia.
- Zinc supplementation was noted during the period of elevated ALP.
- The condition resolved without intervention, confirming its transient nature.
Implications:
- Accurate identification of benign transient hyperphosphatasemia is crucial for pediatricians.
- Awareness of this condition can prevent unnecessary diagnostic investigations and associated costs.
- Highlighting this entity in infancy and childhood aids in appropriate clinical management.
Abstract:
Benign transient hyperphosphatasemia is characterized by a significant increase in alkaline phosphatase levels, which is detected incidentally in infancy and children without underlying bone and liver disease. This condition is a biochemical disorder rather than a clinical disorder and resolves within a short duration. Recognition of this entity by pediatricians is important to avoid unnecessary investigations. Here, we report an infant who was diagnosed as having benign transient hyperphosphatasemia based on clinical and laboratory findings who had increased alkaline phosphatase levels during zinc supplementation, with the aim of highlighting benign transient hyperphosphatasemia in infancy and childhood.
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