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Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic
Urszula Grzybowska-Chlebowczyk1, Paulina Wysocka-Wojakiewicz2, Martyna Jasielska2
1Department of Pediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Insights
Oxidative stress markers in children with inflammatory bowel disease (IBD) were evaluated. Contrary to expectations, IBD patients showed lower oxidized low-density lipoprotein (oxLDL) levels, though longer disease duration correlated with higher oxLDL and anti-oxLDL concentrations.
Area of Science:
- Pediatric Gastroenterology
- Cardiovascular Health
- Oxidative Stress Research
Background:
- Oxidative stress (OS) is increasingly recognized in the pathogenesis of inflammatory bowel disease (IBD).
- Understanding OS status and atherosclerotic risk in pediatric IBD and functional gastrointestinal disorders (FGID) is crucial.
- Previous research suggests a potential link between IBD and altered OS profiles.
Purpose of the Study:
- To assess oxidative and antioxidative stress markers in children diagnosed with IBD.
- To evaluate the risk of the atherosclerotic process in pediatric IBD and FGID patients.
- To compare OS status between children with IBD and FGID.
Main Methods:
- A prospective study involving 71 children over two years.
- Laboratory tests to measure oxidative and antioxidative stress markers.
- Intima-media complex (IMC) measurement in the carotid artery to assess atherosclerotic risk.
Main Results:
- Lower OS values were observed more frequently in children with IBD compared to the FGID group.
- The average concentration of oxidized low-density lipoprotein (oxLDL) was lower in IBD patients.
- In IBD patients, higher oxLDL concentrations were associated with longer disease duration and elevated total cholesterol.
- Higher anti-oxLDL concentrations were also more frequent in IBD patients with longer disease duration.
Conclusions:
- The study did not support the hypothesis of depleted total antioxidant capacity and greater overall OS in pediatric IBD patients.
- Longer disease duration in pediatric IBD is linked to increased concentrations of both oxLDL and anti-oxLDL.
- These findings suggest a complex interplay between IBD duration, OS markers, and potential atherosclerotic risk in children.
Abstract:
Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). The prospective study included a group of 71 children during a period of 2 years. In all children, laboratory tests were performed and intima-media complex in the carotid artery was measured (IMC). Low values of OS were more frequent in children with IBD than in the FGID group. The average concentration of oxidized lipoprotein with average density (oxLDL) was lower in patients with IBD. Among patients with IBD, higher concentrations of oxLDL were recorded in patients with longer-duration disease and with higher concentrations of total cholesterol. In the IBD group, more often, higher concentrations of anti-oxLDL were recorded among patients with longer-duration disease. The obtained results did not support the hypothesis of total antioxidant capacity depletion and greater overall OS in patients with IBD. Patients with IBD with a longer duration of the disease have higher concentrations of oxLDL and anti-oxLDL.
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