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Updated: Feb 6, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
Published on: September 25, 2016
Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors
Alex S Yamashita1, Thiago Belchior1, Fábio S Lira2
1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, Brazil.
Abstract:
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.
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