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Updated: Feb 6, 2026
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In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
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Organism-Level Tumor Models in Zebrafish Danio rerio
I V Mizgirev1, D R Safina2, I V Demidyuk2
1N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia, Leningradskaya Str., 68, Pesochnyy Settlement, St. Petersburg, 197758, Russia.
Acta Naturae
|August 18, 2018
Summary
Zebrafish (Danio rerio) models are increasingly used in cancer research. This review highlights effective zebrafish cancer models, particularly transplantation techniques, for studying tumor formation and growth.
Area of Science:
- Biomedical Research
- Experimental Oncology
- Zebrafish Models
Background:
- Organism-level models are crucial for experimental oncology.
- Zebrafish (Danio rerio) have become popular in cancer research over the last decade.
Purpose of the Study:
- To review methods for developing effective cancer models using Zebrafish.
- To focus on transplantation models and their application in transparent Zebrafish lines.
Main Methods:
- Utilizing optically transparent Zebrafish (Danio rerio) lines.
- Employing tumor transplantation techniques with fluorescently labeled tumors.
- Combining tumor transplantation with fluorescent microscopy and FACS-fractionation.
Main Results:
- Zebrafish models offer a powerful platform for cancer research.
- Transparent Zebrafish lines facilitate detailed observation of tumor dynamics.
- Integration of techniques provides new insights into tumor formation and growth.
Conclusions:
- Zebrafish transplantation models are highly effective for cancer studies.
- Combining advanced techniques enhances the potential of Zebrafish models.
- This approach promises significant contributions to understanding tumor biology.
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