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Related Experiment Video

Updated: Feb 6, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Transpalpebral Electrical Stimulation as a Novel Therapeutic Approach to Decrease Intraocular Pressure for Open-Angle

Félix Gil-Carrasco1, Daniel Ochoa-Contreras1, Marco A Torres1

  • 1Glaucoma Department, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México I.A.P, Mexico City, Mexico.

Journal of Ophthalmology
|August 18, 2018
PubMed
Summary
This summary is machine-generated.

Transpalpebral electrical stimulation significantly lowered intraocular pressure (IOP) in open-angle glaucoma patients. This novel approach proved effective for both treatment-naïve individuals and those on maximum medical therapy.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
  • Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma progression.
  • Current treatments aim to reduce IOP but can have side effects or limited efficacy.

Purpose of the Study:

  • To evaluate the efficacy of transpalpebral electrical stimulation in reducing IOP.
  • To assess the hypotensive effect in patients with primary open-angle glaucoma (POAG).
  • To compare outcomes in treatment-naïve patients versus those on maximal medical therapy.

Main Methods:

  • Prospective, comparative, experimental pilot study design.
  • Application of 10 Hz, biphasic electrical current pulses (100 µA) via transpalpebral stimulation.
  • IOP measurements taken at baseline, before and after stimulation, and at a four-month follow-up.

Main Results:

  • Study included 78 eyes from 46 POAG patients (58 treated, 20 naïve).
  • Mean baseline IOP was 19.25 mmHg (treated) and 20.38 mmHg (naïve).
  • At four months, mean IOP decreased significantly to 14.41 mmHg (treated, P < 0.0001) and 15.29 mmHg (naïve, P < 0.0001).

Conclusions:

  • Transpalpebral electrical stimulation demonstrated a statistically significant IOP-lowering effect in POAG patients.
  • The treatment was effective in both treatment-naïve and medically treated patient groups.
  • This non-invasive electrical stimulation presents a promising new therapeutic avenue for glaucoma management.