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Generalized Edema Caused by Albiglutide: A Case Report.

Kashif Aziz1, Amir Shahbaz1, Paria Zarghamravanbakhsh2

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Cureus
|August 18, 2018
PubMed
Summary

This case study reports generalized edema as a potential side effect of albiglutide, a GLP-1 receptor agonist used for type-2 diabetes. Discontinuation of albiglutide led to the resolution of edema.

Keywords:
albiglutidegeneralized edemaglp-1liraglutidetype 2 diabetes mellitus

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Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Albiglutide is a weekly injectable glucagon-like peptide-1 (GLP-1) receptor agonist for type-2 diabetes management.
  • Known adverse effects include cardiovascular, renal, gastrointestinal, and injection-site reactions.

Observation:

  • A 35-year-old female with type-2 diabetes developed generalized edema after initiating albiglutide therapy.
  • Physical examination and laboratory tests (thyroid, albumin, renal function) were unremarkable and did not explain the edema.

Findings:

  • Discontinuation of albiglutide resulted in the complete resolution of the patient's generalized edema.
  • This suggests a potential causal link between albiglutide and drug-induced generalized edema.

Implications:

  • Highlights a previously unreported adverse effect of albiglutide.
  • Clinicians should consider albiglutide-induced edema in patients presenting with unexplained generalized edema.
  • Further investigation into GLP-1 receptor agonists and fluid retention is warranted.