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Functioning insulinoma with a twenty-year history.

P A Rubio, E A Orzeck, E M Farrell

    International Surgery
    |July 1, 1985
    PubMed
    Summary

    A rare functioning beta islet cell tumor (insulinoma) caused severe hypoglycemia for two decades. Pancreatic angiography led to diagnosis and surgical removal, resulting in a full recovery.

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    Area of Science:

    • Endocrinology
    • Surgical Oncology
    • Gastroenterology

    Background:

    • Beta islet cell tumors, or insulinomas, are rare neuroendocrine neoplasms.
    • These tumors can cause significant morbidity due to excessive insulin secretion.
    • Prolonged, undiagnosed hypoglycemia poses serious health risks.

    Observation:

    • A patient presented with a 20-year history of incapacitating hypoglycemia.
    • Symptoms were refractory to initial management, suggesting an underlying organic cause.
    • Diagnostic challenges in identifying the source of hyperinsulinism were noted.

    Findings:

    • Pancreatic angiography successfully localized a functioning beta islet cell tumor (insulinoma).
    • Surgical excision via laparotomy achieved complete tumor removal.
    • Post-operative follow-up confirmed resolution of hypoglycemia and normalization of glucose levels.

    Implications:

    • Early and accurate diagnosis of insulinoma is crucial for effective management.
    • Pancreatic angiography remains a valuable tool in localizing occult insulinomas.
    • Surgical intervention offers a curative option for functioning beta islet cell tumors, significantly improving patient outcomes.

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