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Terbinafine-induced liver injury

Madhu Kaushal1, Priyanka Tolani1, Navneet Kumar1

  • 1Department of Medicine, Northern Railway Central Hospital, Basant Lane, New Delhi, India.

The National Medical Journal of India
|August 18, 2018
PubMed

Insights

Terbinafine, an antifungal drug, can rarely cause liver injury. Early diagnosis of drug-induced liver injury is crucial to prevent severe liver damage.

Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Terbinafine is a widely prescribed antifungal medication.
  • Drug-induced liver injury (DILI) is a significant clinical concern.
  • Reports of terbinafine-associated hepatotoxicity are infrequent.

Observation:

  • A 64-year-old male patient developed liver injury.
  • The patient was treated with terbinafine.
  • Clinical presentation suggested terbinafine-induced liver injury.

Findings:

  • This case highlights a rare instance of terbinafine-induced liver injury.
  • The patient's liver injury was attributed to terbinafine exposure.
  • Prompt identification of DILI is essential.

Implications:

  • Early diagnosis of DILI can prevent progression to chronic liver disease.
  • Awareness of potential hepatotoxicity is important for clinicians prescribing terbinafine.
  • This case underscores the need for vigilance in monitoring liver function during antifungal therapy.

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