Related Experiment Video
Updated: Feb 6, 2026

07:44
The Spared Nerve Injury SNI Model of Induced Mechanical Allodynia in Mice
Published on: August 18, 2011
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Selective Decrease in Allodynia With High-Frequency Neuromodulation via High-Electrode-Count Intrafascicular
Christopher C Duncan1, David T Kluger1, Tyler S Davis1
1Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.
Summary
Kilohertz high-frequency alternating current (KHFAC) nerve stimulation selectively reduced pain sensitivity using intrafascicular electrodes. This approach preserved essential sensory and motor functions, offering a potential new treatment for chronic peripheral nerve pain.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pain Management
Background:
- Kilohertz high-frequency alternating current (KHFAC) electrical nerve stimulation can reversibly block peripheral nerves in chronic pain patients.
- Previous studies verified KHFAC using nonselective extrafascicular electrodes.
- The efficacy of selective nerve block using intrafascicular electrodes remains less documented.
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