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Related Concept Videos

Frequency-dependent Selection01:21

Frequency-dependent Selection

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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Spinal Nerves: Plexus II01:21

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
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Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
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Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
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Decreasing Function01:27

Decreasing Function

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A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Related Experiment Video

Updated: Feb 6, 2026

The Spared Nerve Injury SNI Model of Induced Mechanical Allodynia in Mice
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Selective Decrease in Allodynia With High-Frequency Neuromodulation via High-Electrode-Count Intrafascicular

Christopher C Duncan1, David T Kluger1, Tyler S Davis1

  • 1Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|August 18, 2018
PubMed
Summary
This summary is machine-generated.

Kilohertz high-frequency alternating current (KHFAC) nerve stimulation selectively reduced pain sensitivity using intrafascicular electrodes. This approach preserved essential sensory and motor functions, offering a potential new treatment for chronic peripheral nerve pain.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pain Management

Background:

Keywords:
Allodynianerve blockneuromodulationneuropathic painperipheral nerve stimulation

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  • Kilohertz high-frequency alternating current (KHFAC) electrical nerve stimulation can reversibly block peripheral nerves in chronic pain patients.
  • Previous studies verified KHFAC using nonselective extrafascicular electrodes.
  • The efficacy of selective nerve block using intrafascicular electrodes remains less documented.