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Reciprocal relationship between herpes zoster and cardiovascular diseases: A nationwide population-based case-control

Hyun-Min Seo1, Myung-Jin Cha2, Ju Hee Han3

  • 1Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

The Journal of Dermatology
|August 18, 2018
PubMed

Insights

Severe herpes zoster (HZ) requiring hospitalization increases the risk of heart attack, stroke, and heart failure. Cardiovascular disease also elevates the risk of hospitalization for HZ, indicating a two-way link.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Herpes zoster (HZ) is a known risk factor for stroke.
  • Limited research exists on the association between HZ and other cardiovascular diseases (CVD) like myocardial infarction (MI) and heart failure (HF).

Purpose of the Study:

  • To investigate the bidirectional relationship between HZ and CVD, including MI, ischemic stroke, and HF.
  • To determine the risk of CVD following HZ and the risk of HZ following CVD.

Main Methods:

  • Retrospective case-control study.
  • Utilized the National Health Insurance System claims database (2006-2013).
  • Included 20,311 patients with HZ, 13,980 patients with CVD, and matched controls.

Main Results:

  • Severe HZ requiring hospitalization significantly increased the risk of subsequent MI (HR 1.831), ischemic stroke (HR 1.523), and HF (HR 2.034).
  • Patients with MI (HR 1.625), ischemic stroke (HR 1.518), or HF (HR 1.485) had a higher risk of HZ hospitalization.
  • A significant reciprocal relationship was observed between severe HZ and CVD.

Conclusions:

  • Severe HZ requiring hospitalization is an independent risk factor for MI, ischemic stroke, and HF.
  • CVD (MI, ischemic stroke, HF) increases the risk of HZ hospitalization.
  • A significant bidirectional association exists between severe HZ and major cardiovascular events.

Keywords:
heart failureherpes zostermyocardial infarctionnational health programsstroke

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