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The pleiotropic role of interleukin-17 in atherosclerosis

Gamal Allam1, Adel Abdel-Moneim2, Asmaa M Gaber2

  • 1Immunology Section, Department of Microbiology, College of Medicine, Taif University, Taif, Saudi Arabia; Immunology Section, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 19, 2018
PubMed

Insights

Interleukin-17 (IL-17) has complex roles in atherosclerosis, a key driver of cardiovascular disease. This review explores IL-17

Area of Science:

  • Immunology
  • Cardiovascular Research
  • Inflammation

Background:

  • Atherosclerosis, a chronic arterial wall inflammation, drives cardiovascular diseases (CVDs), the leading global cause of mortality.
  • Immune cells, including CD4+ T cell subtypes, significantly influence lipoprotein modification and plaque development in atherosclerosis.
  • While T helper-1 (Th1) cells are proatherogenic and T regulatory (Treg) cells are atheroprotective, the role of T helper-17 (Th17) cells and IL-17 remains debated.

Purpose of the Study:

  • To review the current understanding of the dual roles of Interleukin-17 (IL-17) in atherogenesis and plaque stability.
  • To discuss the synergistic and antagonistic interactions of IL-17 with other cytokines in the context of atherosclerosis.
  • To explore the potential for developing novel therapeutic strategies targeting IL-17 pathways for atherosclerosis treatment.

Main Methods:

  • Comprehensive literature review of recent investigations on IL-17 and its role in atherosclerosis.
  • Analysis of studies examining both proatherogenic and atheroprotective effects of IL-17.
  • Discussion of cytokine interactions involving IL-17 in the context of arterial wall inflammation.

Main Results:

  • Evidence suggests IL-17 can exert both proatherogenic and atheroprotective effects in atherosclerosis, depending on the context.
  • The precise role of IL-17 in disease progression and plaque destabilization is still under investigation and considered debatable.
  • Interactions between IL-17 and other inflammatory cytokines significantly modulate its impact on atherosclerosis.

Conclusions:

  • The role of IL-17 in atherosclerosis is complex and context-dependent, presenting challenges for therapeutic targeting.
  • Further research into the intricate mechanisms of IL-17 signaling and its interactions is crucial for understanding its impact on cardiovascular disease.
  • Elucidating these roles may pave the way for innovative therapeutic strategies aimed at managing atherosclerosis.

Keywords:
AtherosclerosisCardiovascular diseasesInterleukin-17

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