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Magnetohydrodynamic blood flow in patients with coronary artery disease
Ashkan Javadzadegan1, Abouzar Moshfegh1, Hamid Hassanzadeh Afrouzi2
1Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; ANZAC Research Institute, The University of Sydney, Sydney, NSW 2139, Australia; Concord Repatriation General Hospital, Sydney Local Health District, NSW 2139, Australia.
Objectives:
We aim to investigate the effect of a magnetic field with varying intensities on haemodynamic perturbations in a cohort of patients with coronary artery disease.
Methods:
Transient computational fluid dynamics (CFD) simulations were performed in three-dimensional (3D) models of coronary arteries reconstructed from 3D quantitative coronary angiography. The effect of magnetic field on wall shear stress (WSS) derived parameters including maximum wall shear stress (MWSS) and size of regions with low wall shear stress (ALWSS) as well as length of flow recirculation zones were determined.
Results:
The results showed a substantial reduction in MWSS, ALWSS and length of flow recirculation zones in the presence of magnetic field, in particular for coronaries with moderate to severe stenoses. When the whole cohort examined, time-averaged wall shear stress (TAWSS), ALWSS and the length of flow recirculation zones in the absence of magnetic field were approximately 1.71, 4.69 and 8.46 times greater than those in the presence of magnetic field, respectively.
Conclusion:
Our findings imply that an externally applied magnetic field can improve haemodynamic perturbations in human coronary arteries.
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Blood Flow