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Two subtypes of symptomatic joint hypermobility: a descriptive study using latent class analysis

Francesco Di Mattia1, Robyn Fary1, Kevin J Murray2

  • 1School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia.

Archives of Disease in Childhood
|August 19, 2018
PubMed

Insights

This study identified two distinct subgroups of children with symptomatic joint hypermobility: athletic-persistent and systemic-profound. These findings aid in understanding and managing hypermobility in pediatric rheumatology.

Area of Science:

  • Pediatric Rheumatology
  • Clinical Genetics
  • Musculoskeletal Disorders

Background:

  • Symptomatic joint hypermobility in children presents a diagnostic challenge.
  • Understanding distinct clinical phenotypes is crucial for effective management.
  • Previous research has not clearly delineated subgroups within this pediatric cohort.

Purpose of the Study:

  • To investigate and identify distinct subgroups within a cohort of children experiencing symptomatic joint hypermobility.
  • To analyze clinical presentations, medical history, psychosocial factors, and physical examination findings.
  • To inform clinical decision-making and management strategies for pediatric hypermobility.

Main Methods:

  • Retrospective review of case notes for 318 children with joint hypermobility.
  • Latent class analysis utilizing seven key extracted variables.
  • Identification of subgroups based on clinical presentation, medical history, and examination findings.

Main Results:

  • Two distinct subgroups were identified: 'athletic-persistent' (62%) and 'systemic-profound' (38%).
  • The 'athletic-persistent' group exhibited recurrent musculoskeletal pain and less severe hypermobility.
  • The 'systemic-profound' group presented with generalized hypermobility, pain, gastro-oesophageal reflux, and motor delay.

Conclusions:

  • The study confirms two distinct clinical presentations in children with symptomatic joint hypermobility.
  • These findings have significant implications for tailored clinical management and treatment approaches.
  • Further research into these subgroups may optimize patient outcomes in pediatric rheumatology.
Abstract

Keywords:
developmental coordination disorderhypermobilityhypermobility spectrum disorderjoint hypermobility syndromemusculoskeletal pain

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