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Hyperuricemia is associated with atrial fibrillation prevalence in very elderly - a community based study in Chengdu,

Gang Huang1,2, Rong-Hua Xu3, Jun-Bo Xu3,4

  • 1Cardiovascular and Metabolic Disease Center, The Second People's Hospital of Chengdu, Chengdu, China. oigg1982@gmail.com.

Scientific Reports
|August 19, 2018
PubMed

Insights

Hyperuricemia, high uric acid levels, increases the risk of atrial fibrillation (AF) in the very elderly. This study found a significant association between elevated serum uric acid and AF prevalence in older Chinese adults.

Area of Science:

  • Cardiology
  • Geriatrics
  • Metabolic Disorders

Background:

  • Hyperuricemia is a known cardiovascular disease risk factor.
  • The association between hyperuricemia and atrial fibrillation (AF) in the very elderly population remains unclear.

Purpose of the Study:

  • To investigate the relationship between hyperuricemia and the prevalence of AF in community-dwelling very elderly individuals.
  • To identify risk factors for AF in this specific demographic.

Main Methods:

  • A cross-sectional study involving 1038 very elderly Chinese participants (mean age 83.6 years).
  • Serum uric acid (SUA) levels were measured.
  • Resting 12-lead electrocardiograms were performed to diagnose AF.
  • Multiple logistic regression analysis was employed to assess risk factors.

Main Results:

  • The prevalence of AF was 5.3% in the study population.
  • Participants with hyperuricemia (defined by sex-specific SUA thresholds) exhibited a significantly higher risk of AF (OR: 2.080, 95% CI: 1.103-4.202, P=0.007).
  • No significant sex difference in AF prevalence was observed.

Conclusions:

  • Atrial fibrillation is relatively common among very elderly Chinese in Chengdu.
  • Hyperuricemia is significantly associated with the prevalence of AF in the very elderly population.
  • Elevated SUA levels may serve as a potential risk indicator for AF in older adults.

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